Cutting Edge: CD91-Independent Cross-Presentation of GRP94(gp96)-Associated Peptides

GRP94(gp96)-Associated Peptides Cross-Presentation of Cutting Edge: CD91-Independent

Cutting edge: CD91-independent cross-presentation of GRP94(gp96)-associated peptides.

GRP94(gp96) elicits CD8(+) T cell responses against its bound peptides, a process requiring access of its associated peptides into the MHC class I cross-presentation pathway of APCs. Entry into this pathway requires receptor-mediated endocytosis, and CD91 (low-density lipoprotein receptor-related protein) has been reported to be the receptor mediating GRP94 uptake into APC. However, a direct ro...

Cutting edge: class I presentation of host peptides following HIV infection.

Class I MHC molecules bind intracellular peptides for presentation to cytotoxic T lymphocytes. Identification of peptides presented by class I molecules during infection is therefore a priority for detecting and targeting intracellular pathogens. To understand which host-encoded peptides distinguish HIV-infected cells, we have developed a mass spectrometric approach to characterize HLA-B*0702 p...

Cutting Edge: Antigen-Independent CD8 T Cell

Cutting Edge Cutting Edge: Acute Lung Allograft Rejection Is Independent of Secondary Lymphoid Organs

It is the prevailing view that adaptive immune responses are initiated in secondary lymphoid organs. Studies using alymphoplastic mice have shown that secondary lymphoid organs are essential to initiate allograft rejection of skin, heart, and small bowel. The high immunogenicity of lungs is well recognized and allograft rejection remains a major contributing factor to poor outcomes after lung t...